Pharmacokinetics and relative bioavailability of oral theophylline capsules.

  title={Pharmacokinetics and relative bioavailability of oral theophylline capsules.},
  author={Lawrence J. Lesko and Andrew T. Canada and Gregory L. Eastwood and Derek H. T. Walker and D R Brousseau},
  journal={Journal of pharmaceutical sciences},
  volume={68 11},
The oral bioavailability of liquid-filled theophylline capsules relative to a nonalcoholic aminophylline solution was determined in normal volunteers. In addition, theophylline absorption and elimination kinetics were reexamined. There were no statistically significant differences between the bioavailability of capsules and liquid as measured by the area under the curve (AUC) from time 0 leads to infinity (p greater than 0.05). The bioavailability parameters of Cmax, tmax, and AUC were… CONTINUE READING

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