Pharmacokinetics and relative bioavailability of fentanyl pectin nasal spray 100 - 800 µg in healthy volunteers.

@article{Fisher2010PharmacokineticsAR,
  title={Pharmacokinetics and relative bioavailability of fentanyl pectin nasal spray 100 - 800 µg in healthy volunteers.},
  author={Anthony N. Fisher and M. Boriqi J. R. Watling and Alan P. Smith and Alastair Knight},
  journal={International journal of clinical pharmacology and therapeutics},
  year={2010},
  volume={48 12},
  pages={860-7}
}
OBJECTIVES Fentanyl pectin nasal spray (FPNS) is formulated as a solution utilizing PecSys®; pectin based enabling technology (Archimedes). On contact with the nasal mucosa the formulation will gel and modulate fentanyl absorption while limiting nasal drip or runoff. This single-dose volunteer study compared the pharmacokinetics of FPNS 100, 200, 400, and 800 µg doses and assessed bioavailability relative to oral transmucosal fentanyl (OTFC) 200 µg. Safety and dose proportionality were also… CONTINUE READING
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