Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals

@article{Sica2004PharmacokineticsAP,
  title={Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals},
  author={Domenic A. Sica and Thomas J. Comstock and J. Davis and L Manning and Robert Powell and Armen P. Melikian and George Joseph Wright},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={39},
  pages={193-194}
}
SummaryWe determined plasma methocarbamol concentrations over 24 h following a 1.5 g methocarbamol dose (off-dialysis day) to 8 chronic haemodialysis patients and compared these results to those from 17 healthy male volunteers.The harmonic mean elimination half-life was similar between the two groups, 1.24 and 1.14 h, respectively. tmax and the weight-adjusted Cmax were 1.1 h and 27.0 mg · m−1 for haemodialysis patients and 1.1 and 23.1 mg · l−1 for normals. Relative systemic availability was… 
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References

SHOWING 1-7 OF 7 REFERENCES
Renal disease and drug metabolism: an overview.
  • T. Gibson
  • Medicine, Biology
    American journal of kidney diseases : the official journal of the National Kidney Foundation
  • 1986
Method of estimating relative absorption of a drug in a series of clinical studies in which blood levels are measured after single and/or multiple doses.
  • J. Wagner
  • Medicine
    Journal of pharmaceutical sciences
  • 1967
TLDR
The method described provides estimates of average relative absorption of a drug administered to different panels of subjects in a series of clinical trials in which blood levels are measured after either single and/or multiple doses of the drug.
Metabolism of methocarbamol in the rat, dog, and human.
Methocarbamol-14C has been shown to be metabolized in the dog, rat, and man by dealkylation, hydroxylation, and conjugation with glucuronide and sulfate. Two metabolites have been isolated and
Liver dysfunction in dialysis patients.
Glucuronidation and disposition of drug glucuronides in patients with renal failure. A review.
  • R. Verbeeck
  • Medicine
    Drug metabolism and disposition: the biological fate of chemicals
  • 1982
Uremia and the liver. II. Drugs and the liver in the uremic patient.
Fundamentals of Clinical Pharmacokinetics