Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals

  title={Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals},
  author={Domenic A. Sica and Thomas J. Comstock and J. Davis and L Manning and Robert Powell and Armen P. Melikian and George Joseph Wright},
  journal={European Journal of Clinical Pharmacology},
SummaryWe determined plasma methocarbamol concentrations over 24 h following a 1.5 g methocarbamol dose (off-dialysis day) to 8 chronic haemodialysis patients and compared these results to those from 17 healthy male volunteers.The harmonic mean elimination half-life was similar between the two groups, 1.24 and 1.14 h, respectively. tmax and the weight-adjusted Cmax were 1.1 h and 27.0 mg · m−1 for haemodialysis patients and 1.1 and 23.1 mg · l−1 for normals. Relative systemic availability was… 
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