Pharmacokinetics and protein binding of prednisolone after oral and intravenous administration

@article{Bergrem2004PharmacokineticsAP,
  title={Pharmacokinetics and protein binding of prednisolone after oral and intravenous administration},
  author={H. Bergrem and P. Gr{\o}ttum and H. Rugstad},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={24},
  pages={415-419}
}
SummaryThe pharmacokinetics of prednisolone after oral and intravenous administration of 10 and 20 mg have been studied. Serum protein binding of prednisolone was also measured after the i.v. injections. The bioavailability after oral administration was 84.5% after 10 mg and 77.6% after 20 mg (p>0.05). Dose dependent pharmacokinetics were found, the VDss and Clt being significantly larger (p<0.01) after 20 mg i.v. than after 10 mg i.v. The protein binding of prednisolone in all subjects was non… Expand
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