Pharmacokinetics and protein adduct formation of the pharmacologically active acyl glucuronide metabolite of mycophenolic acid in pediatric renal transplant recipients.

@article{Shipkova2002PharmacokineticsAP,
  title={Pharmacokinetics and protein adduct formation of the pharmacologically active acyl glucuronide metabolite of mycophenolic acid in pediatric renal transplant recipients.},
  author={Maria Shipkova and Victor William Armstrong and Lutz Weber and Paul Dieter Niedmann and Eberhard Wieland and Jane C Haley and Burkhard Toenshoff and Michael Oellerich},
  journal={Therapeutic drug monitoring},
  year={2002},
  volume={24 3},
  pages={390-9}
}
The acyl glucuronide metabolite (AcMPAG) of mycophenolic acid (MPA) has been found to possess both immunosuppressive and pro-inflammatory activity in vitro. In this study its pharmacokinetics were determined in pediatric renal transplant recipients receiving cyclosporine, steroids, and mycophenolate mofetil. Twelve-hour concentration-time profiles for AcMPAG, MPA, and the phenolic glucuronide (MPAG) were determined by high-performance liquid chromatography (HPLC) in the initial (1-3 wk; n = 16… CONTINUE READING
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