Pharmacokinetics and preliminary efficacy of two vaginal gel formulations of ultra-low-dose estriol in postmenopausal women.

Abstract

OBJECTIVES To investigate the pharmacokinetics, safety and preliminary effectiveness of ultra-low-dose estriol vaginal gel formulations (20 μg/g (T1) and 50 μg/g (T2)) compared to Ovestinon® (estriol 500 μg/0.5 g (R)) and placebo in postmenopausal women. METHODS Forty-three volunteers were randomly assigned to received T1, T2, R or placebo once daily for… (More)
DOI: 10.3109/13697137.2015.1098609

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