• Biology, Medicine
  • Published in
    Canadian journal of…
    2003

Pharmacokinetics and plasma concentrations of acetylsalicylic acid after intravenous, rectal, and intragastric administration to horses.

@article{Broome2003PharmacokineticsAP,
  title={Pharmacokinetics and plasma concentrations of acetylsalicylic acid after intravenous, rectal, and intragastric administration to horses.},
  author={T. A. Broome and Murray P. Brown and Ronald R Gronwall and Matthew Casey and Kelly A Meritt},
  journal={Canadian journal of veterinary research = Revue canadienne de recherche veterinaire},
  year={2003},
  volume={67 4},
  pages={
          297-302
        }
}
Six healthy adult horses (5 mares and 1 stallion) were given a single dose of acetylsalicylic acid (ASA), 20 mg/kg of body weight, by intravenous (IV), rectal, and intragastric (IG) routes. Serial blood samples were collected via jugular venipuncture over a 36-h period, and plasma ASA and salicylic acid (SA) concentrations were determined by high-performance liquid chromatography. After IV administration, the mean elimination rate constant of ASA (+/- the standard error of the mean) was 1.32… CONTINUE READING

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