Pharmacokinetics and pharmacodynamics of vecuronium in the obese surgical patient.

@article{Schwartz1992PharmacokineticsAP,
  title={Pharmacokinetics and pharmacodynamics of vecuronium in the obese surgical patient.},
  author={Ariel Elizabeth Schwartz and Richard S. Matteo and Eugene J. Ornstein and Jonathan D. Halevy and Juli{\'a}n Roberto Hern{\'a}ndez D{\'i}az},
  journal={Anesthesia and analgesia},
  year={1992},
  volume={74 4},
  pages={
          515-8
        }
}
The effect of obesity on the disposition and action of vecuronium was studied in 14 surgical patients. After induction of anesthesia with thiopental and maintenance of anesthesia by inhalation of nitrous oxide and halothane, seven obese patients (93.4 +/- 13.9 kg, 166% +/- 30% of ideal body weight, mean +/- SD) and seven control patients (60.9 +/- 12.3 kg, 93% +/- 6% of ideal body weight) received 0.1 mg/kg of vecuronium. Plasma arterial concentrations of muscle relaxant were determined at 1, 3… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 28 CITATIONS

Which weight for weight-based dosage regimens in obese patients?

  • American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • 2002
VIEW 7 EXCERPTS
CITES METHODS
HIGHLY INFLUENCED

Anesthesia for pediatric obesity.

  • Anesthesiology clinics of North America
  • 2005
VIEW 9 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED