Pharmacokinetics and pharmacodynamics of various glucagon dosages at different blood glucose levels.

@article{Blauw2016PharmacokineticsAP,
  title={Pharmacokinetics and pharmacodynamics of various glucagon dosages at different blood glucose levels.},
  author={Helga Blauw and I Wendl and J. Hans DeVries and Tim Heise and Thomas W. Jax},
  journal={Diabetes, obesity & metabolism},
  year={2016},
  volume={18 1},
  pages={34-9}
}
AIMS To evaluate the pharmacokinetics and pharmacodynamics of different doses of glucagon administered subcutaneously (s.c.) at different blood glucose levels. METHODS This study was an open-label, randomized, three-period, cross-over experiment in 6 patients with type 1 diabetes. During each of the three periods, different blood glucose levels were established in four consecutive steps (8, 6, 4 and 2.8 mmol/l) and glucagon was given at each blood glucose level in doses from 0.11 to 0.44 mg… CONTINUE READING
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