Pharmacokinetics and pharmacodynamics of topotecan in patients with advanced cancer.

@article{Grochow1992PharmacokineticsAP,
  title={Pharmacokinetics and pharmacodynamics of topotecan in patients with advanced cancer.},
  author={Louise B. Grochow and Eric K. Rowinsky and Richard Johnson and Susan M. Ludeman and Scott H. Kaufmann and Francis L. McCabe and Brian Richard Smith and L A Hurowitz and A Delisa and Ross C. Donehower},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1992},
  volume={20 5},
  pages={706-13}
}
Topotecan, a semisynthetic water-soluble analog of camptothecin, is the first topoisomerase I-directed drug to enter clinical trial in the United States in over 20 yr. In this study, 30-min infusions of topotecan were administered daily for 5 days every 3 weeks at doses ranging from 0.5 to 2.5 mg/m2. Topotecan is reversibly hydrolyzed in a pH-dependent reaction in aqueous solutions to the ring-open hydroxy acid. The disposition of the closed ring lactone has been studied in 26 patients, and the… CONTINUE READING

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