Corpus ID: 23143637

Pharmacokinetics and pharmacodynamics of three different prednisolone prodrugs: effect on circulating lymphocyte subsets and function.

@article{Frey1984PharmacokineticsAP,
  title={Pharmacokinetics and pharmacodynamics of three different prednisolone prodrugs: effect on circulating lymphocyte subsets and function.},
  author={B. Frey and C. Walker and F. Frey and A. D. de Weck},
  journal={Journal of immunology},
  year={1984},
  volume={133 5},
  pages={
          2479-87
        }
}
To be pharmacologically active, i.v. prednisolone disodium phosphate (prednisolone phosphate), prednisolone sodium tetrahydrophthalate (prednisolone phthalate), and oral prednisone have to be converted in vivo into prednisolone. The purpose of the present study was to establish whether these agents are functionally equivalent when given in equimolar doses. The peak concentrations of total and unbound prednisolone assessed by HPLC and equilibrium dialysis in five normal volunteers were five to… Expand
Prednisolone concentrations in cerebrospinal fluid after different prednisolone prodrugs.
Clinical Pharmacokinetics of Prednisone and Prednisolone
Kinetics and dynamics of prednisolone.
  • F. Frey
  • Chemistry, Medicine
  • Endocrine reviews
  • 1987
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