Pharmacokinetics and pharmacodynamics of the enantiomers of warfarin in man

@article{Breckenridge1974PharmacokineticsAP,
  title={Pharmacokinetics and pharmacodynamics of the enantiomers of warfarin in man},
  author={A. Breckenridge and M. Orme and H. Wesseling and R. Lewis and R. Gibbons},
  journal={Clinical Pharmacology & Therapeutics},
  year={1974},
  volume={15}
}
  • A. Breckenridge, M. Orme, +2 authors R. Gibbons
  • Published 1974
  • Medicine
  • Clinical Pharmacology & Therapeutics
  • The rate of elimination, apparent volume of distribution, plasma clearance, and relative anticoagulant potency of the enantiomers of warfarin have been determined in man. In 9 subjects the plasma half‐life (T½) of R warfarin after a single oral dose of 0.5 mg/kg ranged from 19.9 to 69.S hours, and was significantly longer than that of S warfarin, which ranged from 18.0 to 34.1 hours. There was no significant difference in the apparent volume of distribution of the enantiomers, and thus the… CONTINUE READING
    262 Citations

    Topics from this paper

    Enantiomers of warfarin and vitamin K1 metabolism.
    • 54
    Stereoselective interaction between the R enantiomer of warfarin and cimetidine.
    • 87
    Pharmacokinetics of warfarin enantiomers: A search for intrasubject correlations
    • 60
    The Effects of Acetaminophen on Pharmacokinetics and Pharmacodynamics of Warfarin
    • 59
    The effect of cimetidine on the steady-state pharmacokinetics and pharmacodynamics of warfarin in humans
    • 19
    Pharmacokinetics of the enantiomers of acenocoumarol in man.
    • 69

    References

    SHOWING 1-10 OF 10 REFERENCES
    Kinetics of warfarin absorption in man
    • 66
    The plasma half lives and the pharmacological effect of the enantiomers of warfarin in rats.
    • A. Breckenridge, M. Orme
    • Chemistry, Medicine
    • Life sciences. Pt. 2: Biochemistry, general and molecular biology
    • 1972
    • 53
    Kinetics of pharmacologic effects in man: The anticoagulant action of warfarin
    • 229
    The assay of warfarin in plasma or stool.
    • 63
    Kinetics of pharmacolog:c effects in man: The anticoagulant action of warfarin, CLIN
    • PHARMACOL. THER
    • 1969
    Studies on the 4-hydroxy coumarins. XVII. The resolution and absolute configuration of warfarin
    • J. Am. Chem. Soc
    • 1961
    Stereochemi - cal considerations of the metabolism of warfarin in man : Studies with the Rand S isomers