Pharmacokinetics and pharmacodynamics of the enantiomers of warfarin in man

  title={Pharmacokinetics and pharmacodynamics of the enantiomers of warfarin in man},
  author={A. Breckenridge and M. Orme and H. Wesseling and R. Lewis and R. Gibbons},
  journal={Clinical Pharmacology & Therapeutics},
  • A. Breckenridge, M. Orme, +2 authors R. Gibbons
  • Published 1974
  • Medicine
  • Clinical Pharmacology & Therapeutics
  • The rate of elimination, apparent volume of distribution, plasma clearance, and relative anticoagulant potency of the enantiomers of warfarin have been determined in man. In 9 subjects the plasma half‐life (T½) of R warfarin after a single oral dose of 0.5 mg/kg ranged from 19.9 to 69.S hours, and was significantly longer than that of S warfarin, which ranged from 18.0 to 34.1 hours. There was no significant difference in the apparent volume of distribution of the enantiomers, and thus the… CONTINUE READING
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