Pharmacokinetics and pharmacodynamics of the enantiomers of warfarin in man

@article{Breckenridge1974PharmacokineticsAP,
  title={Pharmacokinetics and pharmacodynamics of the enantiomers of warfarin in man},
  author={Alasdair M. Breckenridge and M. L. E. Orme and Harry Wesseling and Robin J. Lewis and R T Gibbons},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1974},
  volume={15}
}
The rate of elimination, apparent volume of distribution, plasma clearance, and relative anticoagulant potency of the enantiomers of warfarin have been determined in man. In 9 subjects the plasma half‐life (T½) of R warfarin after a single oral dose of 0.5 mg/kg ranged from 19.9 to 69.S hours, and was significantly longer than that of S warfarin, which ranged from 18.0 to 34.1 hours. There was no significant difference in the apparent volume of distribution of the enantiomers, and thus the… 

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