Pharmacokinetics and pharmacodynamics of sedatives and analgesics in the treatment of agitated critically ill patients.

@article{Wagner1997PharmacokineticsAP,
  title={Pharmacokinetics and pharmacodynamics of sedatives and analgesics in the treatment of agitated critically ill patients.},
  author={Bertil K.J. Wagner and D. A. O'Hara},
  journal={Clinical pharmacokinetics},
  year={1997},
  volume={33 6},
  pages={
          426-53
        }
}
The pharmacokinetics and pharmacodynamics of sedatives and analgesics are significantly altered in the critically ill. These changes may account for the large differences in drug dosage requirements compared with other patient populations. Drugs that in other settings may be considered short-acting often have significantly altered onset and duration of action in critically ill patients, necessitating a change in dosage. Of the benzodiazepines, lorazepam is the drug whose parameters are the… CONTINUE READING
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