Pharmacokinetics and pharmacodynamics of ranitidine in critically ill children.

@article{Lugo2001PharmacokineticsAP,
  title={Pharmacokinetics and pharmacodynamics of ranitidine in critically ill children.},
  author={Ralph A. Lugo and Andrew Marc Harrison and Jared Cash and John C Sweeley and Donald D Vernon},
  journal={Critical care medicine},
  year={2001},
  volume={29 4},
  pages={759-64}
}
OBJECTIVE To determine the pharmacokinetics and pharmacodynamics of ranitidine in critically ill children and to design a dosage regimen that achieves a gastric pH > or =4. DESIGN Prospective, open-label, pharmacokinetic-pharmacodynamic study. SETTING Pediatric intensive care unit in a tertiary care children's hospital. PATIENTS Mechanically ventilated, critically ill children > or =10 kg who required intravenous ranitidine for stress ulcer prophylaxis. INTERVENTIONS Ranitidine… CONTINUE READING