Pharmacokinetics and pharmacodynamics of psoralens after oral administration: considerations and conclusions.

Abstract

We discovered a strong but saturable first-pass effect after oral administration of psoralens by using different doses and simultaneous or timed application of stable isotopes. Therefore, small variations of dose, disintegration of drug, and amount and rate of absorption gave rise to great differences in plasma levels and therapeutic efficacy. For practical… (More)

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