Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: Role of circulating active metabolites

  title={Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: Role of circulating active metabolites},
  author={Bojan Lalovic and E. Kharasch and C. Hoffer and L. Risler and L. Liu-Chen and D. Shen},
  journal={Clinical Pharmacology & Therapeutics},
  • Bojan Lalovic, E. Kharasch, +3 authors D. Shen
  • Published 2006
  • Medicine
  • Clinical Pharmacology & Therapeutics
  • In vitro experiments suggest that circulating metabolites of oxycodone are opioid receptor agonists. Clinical and animal studies to date have failed to demonstrate a significant contribution of the O‐demethylated metabolite oxymorphone toward the clinical effects of the parent drug, but the role of other putative circulating active metabolites in oxycodone pharmacodynamics remains to be examined. 
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