Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: Role of circulating active metabolites

@article{Lalovic2006PharmacokineticsAP,
  title={Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: Role of circulating active metabolites},
  author={Bojan Lalovic and E. Kharasch and C. Hoffer and L. Risler and L. Liu-Chen and D. Shen},
  journal={Clinical Pharmacology & Therapeutics},
  year={2006},
  volume={79}
}
  • Bojan Lalovic, E. Kharasch, +3 authors D. Shen
  • Published 2006
  • Medicine
  • Clinical Pharmacology & Therapeutics
  • In vitro experiments suggest that circulating metabolites of oxycodone are opioid receptor agonists. Clinical and animal studies to date have failed to demonstrate a significant contribution of the O‐demethylated metabolite oxymorphone toward the clinical effects of the parent drug, but the role of other putative circulating active metabolites in oxycodone pharmacodynamics remains to be examined. 
    342 Citations
    The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone
    • 122
    • Highly Influenced
    • PDF
    Genetic polymorphisms and drug interactions modulating CYP2D6 and CYP3A activities have a major effect on oxycodone analgesic efficacy and safety
    • 134
    • Highly Influenced
    Impact of the CYP2D6 genotype on post‐operative intravenous oxycodone analgesia
    • 85
    Pharmacokinetics and Pharmacodynamics of Oxycodone and Morphine with Emphasis on Blood-Brain Barrier Transport
    • 4
    • Highly Influenced
    • PDF
    Physiologically based pharmacokinetic modelling of oxycodone drug-drug interactions.

    References

    SHOWING 1-10 OF 65 REFERENCES
    Effects of blocking CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone
    • 220
    A review of oxycodone's clinical pharmacokinetics and pharmacodynamics.
    • 139
    Tentative identification of novel oxycodone metabolites in human urine.
    • 25
    • PDF
    The pharmacokinetics of oxycodone after intravenous injection in adults.
    • 112
    Inhibition of cytochrome P450 2D6 metabolism of hydrocodone to hydromorphone does not importantly affect abuse liability.
    • 76
    • PDF