Pharmacokinetics and pharmacodynamics of nasally delivered midazolam.

  title={Pharmacokinetics and pharmacodynamics of nasally delivered midazolam.},
  author={Manuel Haschke and K B W S Suter and Sarah Hofmann and Robert Witschi and Johannes Froehlich and Georgios Imanidis and Juergen Drewe and Thomas A. Briellmann and Franz E. Dussy and Stephan Kr{\"a}henb{\"u}hl and Christian Surber},
  journal={British journal of clinical pharmacology},
  volume={69 6},
AIMS To investigate the pharmacokinetics and pharmacodynamics of nasal formulations containing midazolam (5-30 mg ml(-1)) complexed with cyclodextrin. METHODS An open-label sequential trial was conducted in eight healthy subjects receiving single doses of 1 mg and 3 mg intranasally and 1 mg midazolam intravenously. Pharmacokinetic parameters were obtained by non-compartmental and two-compartmental models. Pharmacodynamic effects of midazolam were assessed using VAS and a reaction time test… CONTINUE READING


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