Pharmacokinetics and pharmacodynamics of milrinone in chronic congestive heart failure.

  title={Pharmacokinetics and pharmacodynamics of milrinone in chronic congestive heart failure.},
  author={Joseph R Benotti and Lawrence J. Lesko and Joanne McCue and Joseph Stephen Alpert},
  journal={The American journal of cardiology},
  volume={56 10},
The acute hemodynamic effects and pharmacokinetics of bolus intravenous milrinone administration were assessed in 13 patients with severe congestive heart failure. Serial hemodynamics were measured and blood samples were obtained to determine plasma milrinone concentration and calculation of pharmacokinetic variables after administration of milrinone at 12.5, 25, 50 and 75 micrograms/kg, allowing at least 6 hours to elapse between consecutive milrinone doses. At each dose milrinone effected… CONTINUE READING
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