Pharmacokinetics and pharmacodynamics of levodopa.

  title={Pharmacokinetics and pharmacodynamics of levodopa.},
  author={John G. Nutt},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  volume={23 Suppl 3},
The pharmacokinetics and pharmacodynamics of levodopa are dominated by two features: the short plasma half-life of the drug and the portion of the antiparkinsonian response that parallels the plasma levodopa levels, the so-called short-duration response. These features are the basis of motor fluctuations that complicate long-term therapy with levodopa. Motor fluctuations will predictably improve with measures that prolong the elevations of plasma levodopa or prolong the efficacy of dopamine… CONTINUE READING

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