Pharmacokinetics and pharmacodynamics of ketoprofen in calves applying PK/PD modelling.

@article{Landoni1995PharmacokineticsAP,
  title={Pharmacokinetics and pharmacodynamics of ketoprofen in calves applying PK/PD modelling.},
  author={Maria Fabiana Landoni and Fiona M Cunningham and Peter D Lees},
  journal={Journal of veterinary pharmacology and therapeutics},
  year={1995},
  volume={18 5},
  pages={
          315-24
        }
}
The pharmacokinetics (PK) and pharmacodynamics (PD) of ketoprofen (KTP) were studied in calves following intravenous administration of the drug racemate at a dose rate of 3 mg/kg. To evaluate the anti-inflammatory properties of KTP, a model of acute inflammation, consisting of surgically implanted subcutaneous tissue cages stimulated by intracaveal injection of carrageenan, was used. No differences were observed between disposition curves of KTP enantiomers in plasma, exudate or transudate… CONTINUE READING

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