Pharmacokinetics and pharmacodynamics of methotrexate in non-neoplastic diseases.

  title={Pharmacokinetics and pharmacodynamics of methotrexate in non-neoplastic diseases.},
  author={Jir{\'i} Grim and Jaroslav Chl{\'a}dek and Jiřina Mart{\'i}nkov{\'a}},
  journal={Clinical pharmacokinetics},
  volume={42 2},
Low dose pulse methotrexate (LDMTX) therapy has become effective in the treatment of autoimmune and lymphoproliferative diseases. The pharmacokinetics of LDMTX is individually highly variable, resulting in a different systemic exposure to the drug and a variable therapeutic/toxic effect in patients. The improvements and exacerbations of disease activity in relation to the introductions and discontinuations of LDMTX therapy suggest the possible immunosuppresive and anti-inflammatory properties… CONTINUE READING