Pharmacokinetics and pharmacodynamics of single-chain recombinant human follicle-stimulating hormone containing the human chorionic gonadotropin carboxyterminal peptide in the rhesus monkey.

@article{Klein2002PharmacokineticsAP,
  title={Pharmacokinetics and pharmacodynamics of single-chain recombinant human follicle-stimulating hormone containing the human chorionic gonadotropin carboxyterminal peptide in the rhesus monkey.},
  author={Jeffrey Klein and Leslie I. Lobel and Susan V Pollak and Michel J Ferin and Ennian Xiao and Mark V. Sauer and Joyce W. Lustbader},
  journal={Fertility and sterility},
  year={2002},
  volume={77 6},
  pages={1248-55}
}
OBJECTIVE To compare the pharmacokinetics of a long-acting FSH analog containing the hCG-beta carboxyterminal peptide (recombinant hFSH-CTP) with native recombinant hFSH and describe the pharmacodynamics of recombinant hFSH-CTP after SC injection in female rhesus monkeys. DESIGN Rhesus monkey study. SETTING Academic research environment. ANIMAL(S) Ten female rhesus monkeys. INTERVENTION(S) Recombinant hFSH and recombinant hFSH-CTP were administered via a single SC or IV dose to rhesus… CONTINUE READING

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