Pharmacokinetics and pharmacodynamics of psychoactive drugs in old age.

@article{Hesse1982PharmacokineticsAP,
  title={Pharmacokinetics and pharmacodynamics of psychoactive drugs in old age.},
  author={C. Hesse},
  journal={Gerontology},
  year={1982},
  volume={28 Suppl 1},
  pages={
          113-5
        }
}
  • C. Hesse
  • Published 1982
  • Medicine
  • Gerontology
  • It can be shown that aged patients need about 2/3 of the dose of younger adult depressive patients to reach a comparable serum level distribution. No difference could be found between younger and aged patients in the correlation between serum level and clinical outcome. This correlation can best be described as a kind of saturation curve. Taking the vast serum level range in patient collectives in therapy with tri- and tetracyclic antidepressives into consideration, a routine screening of serum… CONTINUE READING
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