Pharmacokinetics and pharmacodynamics of intraperitoneal cancer chemotherapeutics.

  title={Pharmacokinetics and pharmacodynamics of intraperitoneal cancer chemotherapeutics.},
  author={Csilla Hasovits and Stephen Clarke},
  journal={Clinical pharmacokinetics},
  volume={51 4},
Peritoneal carcinomatosis remains a significant cause of morbidity and is a marker of poor prognosis in a range of malignancies, including those of the gastrointestinal and gynaecological tracts. In these cases, regional therapy has been explored as a treatment strategy to take advantage of the prolonged confinement of such tumours within the peritoneal cavity and the steep dose-response relationship for most cytotoxic agents. The pharmacokinetic rationale is based on exploiting the peritoneal… CONTINUE READING
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