Pharmacokinetics and pharmacodynamics of (+)-primaquine and (-)-primaquine enantiomers in rhesus macaques (Macaca mulatta).

  title={Pharmacokinetics and pharmacodynamics of (+)-primaquine and (-)-primaquine enantiomers in rhesus macaques (Macaca mulatta).},
  author={David L. Saunders and Pattaraporn Vanachayangkul and Rawiwan Imerbsin and Phisit Khemawoot and Raveewan 5 Siripokasupkul and Babu L. Tekwani and Aruna Sampath and N. P. Dhammika Nanayakkara and Colin Ohrt and Charlotte Anne Lanteri and Montip Gettyacamin and Paktiya Teja-Isavadharm and Larry A Walker},
  journal={Antimicrobial agents and chemotherapy},
  volume={58 12},
Primaquine (PQ) remains the sole available drug to prevent relapse of Plasmodium vivax malaria more than 60 years after licensure. While this drug was administered as a racemic mixture, prior studies suggested a pharmacodynamic advantage based on differential antirelapse activity and/or toxicities of its enantiomers. Oral primaquine enantiomers prepared using a novel, easily scalable method were given for 7 days to healthy rhesus macaques in a dose-rising fashion to evaluate their effects on… CONTINUE READING