Pharmacokinetics and pharmacodynamics of a therapeutic dose of unfractionated heparin (200 U/kg) administered subcutaneously or intravenously to healthy dogs.

@article{Diqulou2005PharmacokineticsAP,
  title={Pharmacokinetics and pharmacodynamics of a therapeutic dose of unfractionated heparin (200 U/kg) administered subcutaneously or intravenously to healthy dogs.},
  author={Armelle Diqu{\'e}lou and C Barbaste and A M Gabaig and Catherine Trumel and N Abella-Bourges and J F Guelfi and A Bousquet M{\'e}lou},
  journal={Veterinary clinical pathology},
  year={2005},
  volume={34 3},
  pages={237-42}
}
BACKGROUND Heparin treatment has been recommended for dogs in hypercoagulable states such as disseminated intravascular coagulation, however, potential benefits have to be balanced against the bleeding risk if overdosage occurs. A better understanding of the pharmacology of heparin and tests to monitor heparin therapy in dogs may help prevent therapeutic hazards. OBJECTIVES The purpose of this study was to evaluate the effects of 200 U/kg of sodium unfractionated heparin (UFH) on coagulation… CONTINUE READING