Pharmacokinetics and pharmacodynamics of LGD-3303 [9-chloro-2-ethyl-1-methyl-3-(2,2,2-trifluoroethyl)-3H-pyrrolo-[3,2-f]quinolin-7(6H)-one], an orally available nonsteroidal-selective androgen receptor modulator.

Abstract

Selective androgen receptor modulators (SARMs) are a new class of molecules in development to treat a variety of diseases. SARMs maintain the beneficial effects of androgens, including increased muscle mass and bone density, while having reduced activity on unwanted side effects. The mechanisms responsible for the tissue-selective activity of SARMs are not… (More)
DOI: 10.1124/jpet.108.146811

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@article{Vajda2009PharmacokineticsAP, title={Pharmacokinetics and pharmacodynamics of LGD-3303 [9-chloro-2-ethyl-1-methyl-3-(2,2,2-trifluoroethyl)-3H-pyrrolo-[3,2-f]quinolin-7(6H)-one], an orally available nonsteroidal-selective androgen receptor modulator.}, author={Eric G. Vajda and Francisco J. L{\'o}pez and Peter J. Rix and Robert Hill and Yanling Chen and Kyoung-jin Lee and Zhihong O'Brien and William Chozen Chang and Martin D Meglasson and Yong-Hee Lee}, journal={The Journal of pharmacology and experimental therapeutics}, year={2009}, volume={328 2}, pages={663-70} }