Pharmacokinetics and pharmacodynamics of endoperoxide antimalarials.

@article{Gautam2009PharmacokineticsAP,
  title={Pharmacokinetics and pharmacodynamics of endoperoxide antimalarials.},
  author={Anirudh Gautam and Tausif Ahmed and Vijay Batra and Jyoti Paliwal},
  journal={Current drug metabolism},
  year={2009},
  volume={10 3},
  pages={289-306}
}
There are several clinically useful endoperoxides, mainly artemisinin derivatives available in market for the treatment of malaria. These are highly potent drugs, with fastest parasite reduction ratio, broadest parasite stage specificity and effectiveness against all species of plasmodium in human. Endoperoxides are crystalline compounds having poor aqueous solubility. Several theories have been proposed for their mechanism of action, but the understanding is still incomplete. The major… CONTINUE READING

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