Pharmacokinetics and pharmacodynamics after oral and intravenous administration of tolcapone, a novel adjunct to Parkinson's disease therapy

@article{Jorga1998PharmacokineticsAP,
  title={Pharmacokinetics and pharmacodynamics after oral and intravenous administration of tolcapone, a novel adjunct to Parkinson's disease therapy},
  author={K. Jorga and B. Fotteler and P. Heizmann and G. Z{\"u}rcher},
  journal={European Journal of Clinical Pharmacology},
  year={1998},
  volume={54},
  pages={443-447}
}
AbstractObjective: To evaluate fully the pharmacokinetics and pharmacodynamics of tolcapone, a novel inhibitor of catechol-O-methyltransferase (COMT), after oral and intravenous administration. Methods: Sixteen healthy male volunteers were given tolcapone in single doses of 200 mg orally and 50 mg intravenously, separated by a washout period of 7 days or more, in a single-center, open-label, randomized, cross-over study. Pharmacokinetic parameters were calculated using both compartmental and… Expand
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  • Medicine
  • CNS neuroscience & therapeutics
  • 2008
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