Pharmacokinetics and penetration into synovial fluid of systemical and electroporation administered sinomenine to rabbits.

@article{Yan2015PharmacokineticsAP,
  title={Pharmacokinetics and penetration into synovial fluid of systemical and electroporation administered sinomenine to rabbits.},
  author={Huan Yan and Miao Yan and Huan-De Li and Pei Jiang and Yang Deng and Hua-lin Cai},
  journal={Biomedical chromatography : BMC},
  year={2015},
  volume={29 6},
  pages={883-9}
}
Sinomenine is an anti-rheumatoid arthritis (RA) drug derived from the Sinomenium acutum. The major site of RA treatment is within the synovial compartment. However, the pharmacokinetic and penetration into synovial fluid (SF) of sinomenine have not been reported. In our study, the pharmacokinetics and penetration into SF of systemic and electroporation administered sinomenine were investigated by microdialysis incorporated with HPLC-MS/MS. Sinomenine went into plasma and SF more rapidly with… CONTINUE READING

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