Pharmacokinetics and penetration into synovial fluid of systemical and electroporation administered sinomenine to rabbits.

  title={Pharmacokinetics and penetration into synovial fluid of systemical and electroporation administered sinomenine to rabbits.},
  author={Huan Yan and Miao Yan and Huan-De Li and Pei Jiang and Yang Deng and Hua-lin Cai},
  journal={Biomedical chromatography : BMC},
  volume={29 6},
Sinomenine is an anti-rheumatoid arthritis (RA) drug derived from the Sinomenium acutum. The major site of RA treatment is within the synovial compartment. However, the pharmacokinetic and penetration into synovial fluid (SF) of sinomenine have not been reported. In our study, the pharmacokinetics and penetration into SF of systemic and electroporation administered sinomenine were investigated by microdialysis incorporated with HPLC-MS/MS. Sinomenine went into plasma and SF more rapidly with… CONTINUE READING

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Publications referenced by this paper.
Showing 1-10 of 21 references

Development of patch and spray formulations for enhancing topical delivery of sinomenine hydrochloride.

Journal of pharmaceutical sciences • 2010
View 3 Excerpts
Highly Influenced

Pharmacokinetic interaction of paeoniflorin and sinomenine: Biomed. Chromatogr

ZQ Liu, ZH Jiang, +5 authors L. Liu

Determination of sinomenine sustained-release capsules in healthy Chinese volunteers by liquid chromatography-tandem mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences • 2012

Transdermal delivery

JY Fang, JJ Wang, OY. Hu

Intra-articular penetration of ketoprofen and analgesic effects after topical patch application in rats.

Journal of controlled release : official journal of the Controlled Release Society • 2008
View 1 Excerpt

Sinomenine ameliorates arthritis via MMPs, TIMPs, and cytokines in rats.

Biochemical and biophysical research communications • 2008
View 1 Excerpt

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