Pharmacokinetics and organ specific metabolism of glycine-extended and amidated gastrin in sheep.

@article{Ciccotosto1992PharmacokineticsAO,
  title={Pharmacokinetics and organ specific metabolism of glycine-extended and amidated gastrin in sheep.},
  author={Giuseppe Donato Ciccotosto and Arthur Shulkes},
  journal={The American journal of physiology},
  year={1992},
  volume={263 5 Pt 1},
  pages={G802-9}
}
Glycine (Gly)-extended gastrin has been described as the inactive precursor form of the biologically active amidated gastrin. The ratio of Gly-extended to amidated gastrin is higher in the circulation than in tissue, suggesting either differential secretion and/or metabolism. Although the distribution of the precursor form is similar in tissue and… CONTINUE READING