Pharmacokinetics and milk penetration of orbifloxacin after intravenous, subcutaneous, and intramuscular administration to lactating goats.

@article{Marin2007PharmacokineticsAM,
  title={Pharmacokinetics and milk penetration of orbifloxacin after intravenous, subcutaneous, and intramuscular administration to lactating goats.},
  author={Pedro Noheda Marin and Elisa Escudero and E Fern{\'a}ndez-var{\'o}n and Carlos M C{\'a}rceles},
  journal={Journal of dairy science},
  year={2007},
  volume={90 9},
  pages={4219-25}
}
The single-dose disposition kinetics of orbifloxacin were determined in clinically normal lactating goats (n = 6) after intravenous, subcutaneous, and intramuscular administration of 2.5 mg of orbifloxacin/kg of body weight. Orbifloxacin concentrations were determined by HPLC with fluorescence detection. The concentration-time data were analyzed by compartmental and noncompartmental kinetic methods. Steady-state volume of distribution and clearance of orbifloxacin after intravenous… CONTINUE READING