Pharmacokinetics and metabolism of vinca alkaloids.

  title={Pharmacokinetics and metabolism of vinca alkaloids.},
  author={Roger Rahmani and Xuelian Jamie Zhou},
  journal={Cancer surveys},
The anti-mitotic vinca alkaloids, vinblastine, vincristine, vindesine and navelbine, are widely used both as single agents and in combination with other antitumour drugs in cancer chemotherapy. Data on clinical pharmacokinetics following intravenous bolus injection, continuous infusion and oral administration show that vinca alkaloids are characterized by a large apparent total distribution volume, rapid total plasma clearance and a long terminal half-life. Faecal excretion is the main… CONTINUE READING

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