Pharmacokinetics and metabolism of thioridazine during co-administration of tricyclic antidepressants.

@article{Daniel2000PharmacokineticsAM,
  title={Pharmacokinetics and metabolism of thioridazine during co-administration of tricyclic antidepressants.},
  author={Władysława Anna Daniel and Magdalena Syrek and Anna Haduch and Jacek W{\'o}jcikowski},
  journal={British journal of pharmacology},
  year={2000},
  volume={131 2},
  pages={287-95}
}
1. Because of serious side-effects of thioridazine and tricyclic antidepressants (cardiotoxicity), a possible influence of imipramine and amitriptyline on the pharmacokinetics and metabolism of thioridazine was investigated in a steady state (2-week treatment) in rats. 2. Imipramine and amitriptyline (5 and 10 mg kg(-1) i.p., respectively) elevated 30 and 20 fold, respectively, the concentration of thioridazine (10 mg kg(-1) i.p.) and its metabolites (N-desmethylthioridazine, 2-sulphoxide, 2… CONTINUE READING