Pharmacokinetics and metabolism of the new thromboxane A2 receptor antagonist ramatroban in animals. 2nd communication: distribution to organs and tissues in male, female and pregnant rats, and characteristics of protein binding in plasma.

The distribution to organs and tissues, placental transfer and mammary excretion of ramatroban ((+)- (3R)-3-(4-fluorophenylsulfonamido)-1,2,3,4-tetrahydro-9- carbazolepropanoic acid, CAS 116649-85-5, BAY u 3405) have been investigated in rats. Furthermore, the characteristics of protein binding in plasma of various species including man are described. After… CONTINUE READING