Pharmacokinetics and metabolism of sodium 2-mercaptoethanesulfonate in the rat.

@article{Ormstad1983PharmacokineticsAM,
  title={Pharmacokinetics and metabolism of sodium 2-mercaptoethanesulfonate in the rat.},
  author={Kari Ormstad and Sten Orrenius and T L{\aa}stbom and Nobuaki Uehara and Jan Pohl and Jurij Stekar and Norbert Brock},
  journal={Cancer research},
  year={1983},
  volume={43 1},
  pages={333-8}
}
The synthetic low-molecular-weight thiol, 2-mercaptoethanesulfonate (mesna), exerts efficient protection against oxazaphosphorine-induced urothelial toxicity by binding the renally excreted and concentrated toxic metabolite(s). In this study, the pharmacokinetics and metabolism of mesna and its disulfide form (dimesna) have been investigated in the intact rat and in several in vitro systems, including isolated perfused organs, freshly isolated cells, and subcellular fractions; the mechanism of… CONTINUE READING
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