Pharmacokinetics and metabolism of rectally administered paracetamol in preterm neonates.

@article{Lingen1999PharmacokineticsAM,
  title={Pharmacokinetics and metabolism of rectally administered paracetamol in preterm neonates.},
  author={Richard A van Lingen and J. T. Deinum and Jeanette Quak and A. J. Kuizenga and Joanne G van Dam and K. J.S. Anand and D Tibboel and Albert Okken},
  journal={Archives of disease in childhood. Fetal and neonatal edition},
  year={1999},
  volume={80 1},
  pages={F59-63}
}
AIM To investigate the pharmacokinetics, metabolism, and dose-response relation of a single rectal dose of paracetamol in preterm infants in two different age groups. METHODS Preterm infants stratified by gestational age groups 28-32 weeks (group 1) and 32-36 weeks (group 2) undergoing painful procedures were included in this study. Pain was assessed using a modified facies pain score. RESULTS Twenty one infants in group 1 and seven in group 2 were given a single rectal dose of 20 mg/kg… CONTINUE READING