Pharmacokinetics and metabolism of quinidine in extensive and poor metabolisers of sparteine

@article{Mikus1986PharmacokineticsAM,
  title={Pharmacokinetics and metabolism of quinidine in extensive and poor metabolisers of sparteine},
  author={Gerd Mikus and Huy Riem Ha and S. Vo{\vz}eh and C. Zekorn and Ferenc Follath and Michel F Eichelbaum},
  journal={European Journal of Clinical Pharmacology},
  year={1986},
  volume={31},
  pages={69-72}
}
The pharmacokinetics and metabolism of quinidine were investigated in extensive and poor metabolisers of sparteine. No differences in plasma clearance, terminal half life, volume of distribution or cumulative urinary excretion of quinidine, 3-hydroxyquinidine and quinidine-N-oxide were observed between phenotypes. Thus, it is unlikely that quinidine metabolism is controlled by the sparteine/debrisoquine gene locus. 

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The debrisoquine hydroxylation gene: A gene of multiple consequences

  • JR Idle, RL Smith
  • Proceedings of the Second World Conference on…
  • 1984
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