Pharmacokinetics and metabolism of FCE 22101 following its administration as the oral pro-drug FCE 22891.

Abstract

Ten healthy male volunteers who had previously received both intramuscular and intravenous doses of FCE 22101 received a single oral dose of FCE 22891, the acetoxymethyl ester and pro-drug of FCE 22101. After a lag time of 22 min, mean plasma levels of FCE 22101 rose with a T1/2 absorbance of 19 min to 2.5 mg/L at 30 min, 3.6 mg/L at 60 min and a Cmax of 4… (More)

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@article{Lovering1992PharmacokineticsAM, title={Pharmacokinetics and metabolism of FCE 22101 following its administration as the oral pro-drug FCE 22891.}, author={Andy Lovering and Alasdair P Macgowan and D. A. Lewis and D. S. Reeves}, journal={The Journal of antimicrobial chemotherapy}, year={1992}, volume={29 2}, pages={179-85} }