Pharmacokinetics and food interaction of MK-462 in healthy males.

  title={Pharmacokinetics and food interaction of MK-462 in healthy males.},
  author={Haiyung Cheng and William J Polvino and David Sciberras and L Yogendran and Kristine Cerchio and Keith N. Christie and Timothy V. Olah and Debra A McLoughlin and Ian L James and John Douglas Rogers},
  journal={Biopharmaceutics & drug disposition},
  volume={17 1},
A study was conducted to assess the safety, tolerability, and pharmacokinetics of single intravenous (IV) doses of 5-90 micrograms kg-1 of MK-462, and the effect of food on the pharmacokinetics of MK-462 administered orally to healthy males. Results of this study indicate that IV doses of MK-462 from 5 to 90 micrograms kg-1 are well tolerated. The disposition kinetics of MK-462 were linear for IV doses up to and including 60 micrograms kg-1. The values of the plasma clearance (CL), steady-state… CONTINUE READING