Pharmacokinetics and follicular dynamics of corifollitropin alfa versus recombinant FSH during ovarian stimulation for IVF.

@article{Fauser2011PharmacokineticsAF,
  title={Pharmacokinetics and follicular dynamics of corifollitropin alfa versus recombinant FSH during ovarian stimulation for IVF.},
  author={Bart C. J. M. Fauser and Michael M. Alper and William Leigh Ledger and William B. Schoolcraft and Anthe Zandvliet and Bernadette M. J. L. Mannaerts},
  journal={Reproductive biomedicine online},
  year={2011},
  volume={22 Suppl 1},
  pages={S23-31}
}
A single injection of corifollitropin alfa can replace seven daily injections of recombinant FSH (rFSH) using a gonadotrophin-releasing hormone antagonist protocol in ovarian stimulation prior to IVF or intracytoplasmic sperm injection. This double-blind randomized controlled trial assessed the pharmacokinetics and pharmacodynamics of 150 μg corifollitropin alfa versus daily 200 IU rFSH in 1509 patients. Comparative analyses were performed on serum concentrations of FSH immunoreactivity… CONTINUE READING

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