Pharmacokinetics and ex vivo pharmacodynamics of cefquinome in porcine serum and tissue cage fluids.

@article{Zhang2014PharmacokineticsAE,
  title={Pharmacokinetics and ex vivo pharmacodynamics of cefquinome in porcine serum and tissue cage fluids.},
  author={Bingxu Zhang and Xishan Lu and Xiaoyan Gu and Xiaohong Li and Mengxiao Gu and Nan Zhang and Xiangguang Shen and Huanzhong Ding},
  journal={Veterinary journal},
  year={2014},
  volume={199 3},
  pages={399-405}
}
A tissue cage (TC) model was used to evaluate the pharmacokinetics and ex vivo pharmacodynamics of cefquinome after intravenous (IV) and intramuscular (IM) administration to piglets at 2 mg/kg bodyweight. The mean values of area under the concentration-time curve (AUC) were 21.28 (IV) and 21.37 (IM) μg h/mL for serum, and 17.40 (IV) and 16.57 (IM) μg h/mL for TC fluid (TCF), respectively. Values of maximum concentration (C(max)) were 6.15 μg/mL (serum) and 1.15 μg/mL (TCF) after IM… CONTINUE READING

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