Pharmacokinetics and ex vivo antimalarial activity of artesunate-azithromycin in healthy volunteers.

Abstract

In 18 male healthy subjects, artesunate (200 mg)-azithromycin (1,500 mg) daily for 3 days was found to be well tolerated, with only mild gastrointestinal disturbances reported. The pharmacokinetic properties of artesunate-azithromycin given in combination are comparable to those of the drugs given alone. Artesunate and its major active metabolite, dihydroartemisinin, are responsible for most of the ex vivo antimalarial activity, with a delayed contribution by azithromycin.

DOI: 10.1128/AAC.00365-11

Cite this paper

@article{Chinh2011PharmacokineticsAE, title={Pharmacokinetics and ex vivo antimalarial activity of artesunate-azithromycin in healthy volunteers.}, author={Nguyen Trong Chinh and Nguyen Ngoc Quang and Chu Xuan Anh and Nguyen Xuan Thanh and Bui Dai and Geoffrey W. Birrell and Marina Chavchich and Michael D. Edstein}, journal={Antimicrobial agents and chemotherapy}, year={2011}, volume={55 9}, pages={4412-5} }