Pharmacokinetics and efficacy of pulse oral versus intravenous calcitriol in hemodialysis patients.

@article{Levine1996PharmacokineticsAE,
  title={Pharmacokinetics and efficacy of pulse oral versus intravenous calcitriol in hemodialysis patients.},
  author={Barton S. Levine and Meng Song},
  journal={Journal of the American Society of Nephrology : JASN},
  year={1996},
  volume={7 3},
  pages={488-96}
}
Because intravenous (iv) calcitriol has greater bioavailability than oral calcitriol, it may be more efficacious in suppressing parathyroid hormone (PTH) secretion. In this study, the pharmacokinetics and efficacy of pulse oral and i.v. calcitriol were compared. Patients were randomized to receive 2 micrograms of i.v. or oral calcitriol after each dialysis. Two pharmacokinetic studies (PK1, PK2) were performed 10 days apart, during which the patients received calcitriol after each dialysis… CONTINUE READING