Pharmacokinetics and efficacy of a vaginally administered maraviroc gel in rhesus macaques.

@article{Malcolm2013PharmacokineticsAE,
  title={Pharmacokinetics and efficacy of a vaginally administered maraviroc gel in rhesus macaques.},
  author={R. Karl Malcolm and Claire J Forbes and Leslie Geer and Ronald S Veazey and Laurie S. Goldman and Per Johan Klasse and John P. Moore},
  journal={The Journal of antimicrobial chemotherapy},
  year={2013},
  volume={68 3},
  pages={678-83}
}
OBJECTIVES To investigate the pharmacokinetics (PK) of maraviroc, a CCR5-targeted HIV-1 entry inhibitor, in rhesus macaques following vaginal administration of various maraviroc-loaded aqueous hydroxyethylcellulose (HEC) gels, and to correlate the PK data with efficacy in a single high-dose vaginal SHIV-162P3 challenge model. METHODS Maraviroc concentrations in vaginal fluid (Weck-Cel(®) sponge), vaginal tissue (punch biopsy) and plasma were assessed over 72 h following single-dose vaginal… CONTINUE READING
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