Pharmacokinetics and effects of propofol 6% for short-term sedation in paediatric patients following cardiac surgery.

@article{Knibbe2002PharmacokineticsAE,
  title={Pharmacokinetics and effects of propofol 6% for short-term sedation in paediatric patients following cardiac surgery.},
  author={Catherijne A J Knibbe and Gitte Melenhorst-de Jong and Maaike Mestrom and Carin M. A. Rademaker and Allart F A Reijnvaan and Klaas P. Zuideveld and Paul F. M. Kuks and Hans van Vught and Meindert Danhof},
  journal={British journal of clinical pharmacology},
  year={2002},
  volume={54 4},
  pages={415-22}
}
AIMS This paper describes the pharmacokinetics and effects of propofol in short-term sedated paediatric patients. METHODS Six mechanically ventilated children aged 1-5 years received a 6 h continuous infusion of propofol 6% at the rate of 2 or 3 mg kg-1 h-1 for sedation following cardiac surgery. A total of seven arterial blood samples was collected at various time points during and after the infusion in each patient. Pharmacokinetic modelling was performed using NONMEM. Effects were assessed… CONTINUE READING

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