Pharmacokinetics and effect on caffeine metabolism of the proton pump inhibitors, omeprazole, lansoprazole, and pantoprazole.

@article{Andersson1998PharmacokineticsAE,
  title={Pharmacokinetics and effect on caffeine metabolism of the proton pump inhibitors, omeprazole, lansoprazole, and pantoprazole.},
  author={Tommy Andersson and Johan Holmberg and Kerstin R{\"o}hss and Anders Walan},
  journal={British journal of clinical pharmacology},
  year={1998},
  volume={45 4},
  pages={
          369-75
        }
}
AIMS To study the pharmacokinetics of three proton pump inhibitors, omeprazole, lansoprazole, and pantoprazole, as well as any potential influence on CYP1A2 activity (measured by means of rate of caffeine metabolism) of these compounds at single dose and repeated dose administration. METHODS Fourteen healthy males, classified as 12 extensive metabolizers (EMs) and two poor metabolizers (PMs) according to the urinary S/R mephenytoin ratio, completed this open, randomized, three-way cross-over… CONTINUE READING
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