Pharmacokinetics and effect of ticlopidine on platelet aggregation in subjects with normal and impaired renal function.

@article{Buur1997PharmacokineticsAE,
  title={Pharmacokinetics and effect of ticlopidine on platelet aggregation in subjects with normal and impaired renal function.},
  author={T Buur and Rolf Larsson and Ulf R Berglund and François Donat and C Tronquet},
  journal={Journal of clinical pharmacology},
  year={1997},
  volume={37 2},
  pages={108-15}
}
The pharmacokinetics and the effect of ticlopidine on platelet aggregation were determined in patients with chronic renal failure (n = 6), who were not on dialysis and had glomerular filtration of 16.9 +/- 4.4 mL/min, and were matched with the pharmacokinetics and effects in healthy volunteers (n = 7). Participants were studied after acute oral administration of ticlopidine at the beginning of the study and after 36 days of treatment with 250 mg twice daily. For unchanged ticlopidine there were… CONTINUE READING