Pharmacokinetics and dose proportionality of three Tramadol Contramid® OAD tablet strengths

@article{Karhu2007PharmacokineticsAD,
  title={Pharmacokinetics and dose proportionality of three Tramadol Contramid{\textregistered} OAD tablet strengths},
  author={David Karhu and Ali El-Jammal and Thibaut Dupain and Delphine Gaulin and Sylvie Bouchard},
  journal={Biopharmaceutics \& Drug Disposition},
  year={2007},
  volume={28}
}
A three‐way crossover study in 27 human volunteers was conducted to characterize the pharmacokinetics and to assess the dose proportionality of 100 mg, 200 mg and 300 mg strengths of a novel once‐a‐day tramadol controlled‐release tablet (Tramadol Contramid® OAD) following single‐dose administration. Serial blood samples were collected at predefined timepoints over a 48 h period and racemic tramadol and O‐desmethyltramadol concentrations in plasma were determined using a validated LC‐MS/MS… 
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