Pharmacokinetics and dosage recommendations for an oseltamivir oral suspension for the treatment of influenza in children.

@article{Oo2001PharmacokineticsAD,
  title={Pharmacokinetics and dosage recommendations for an oseltamivir oral suspension for the treatment of influenza in children.},
  author={Charles Oo and Joanne Barrett and George Hill and J Mann and Albert E. Dorr and Regina T Dutkowski and Penelope Ward},
  journal={Paediatric drugs},
  year={2001},
  volume={3 3},
  pages={
          229-36
        }
}
OBJECTIVE Oseltamivir (Ro 64-0796) is an ester prodrug of the active metabolite Ro 64-0802 (oseltamivir carboxylate), a potent and selective inhibitor of the neuraminidase enzyme of influenza virus. In this study we report the pharmacokinetics of oseltamivir in healthy children volunteers (study 1) and in children with influenza (study 2). STUDY PARTICIPANTS AND METHODS In study 1, an open-label, single dose study, serial plasma samples were obtained from a total of 18 healthy children (5 to… CONTINUE READING

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